Our long term history therefore should encourage us to be sensitive to transformations in knowledge and in society and to be willing to respond to them by further reinvention. What about our present situation? I see a strong case for fresh reinvention. The core factors are intrinsic to the dynamism of knowledge and its use, and especially its relation to the people who discover it, teach it, learn it, interpret it, and apply it. I would suggest that this university, along with others, is being asked to meet four interconnected challenges simultaneously.